PMID:28337103Įffect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. In addition, from the results of the EMG recording and the behavioral assessment through beam walking, tiagabine is demonstrated as being effective in reducing dystonic spasm and may be a possible alternative therapeutic drug in the treatment of dystonia. The result of this study suggests and confirms that low dose of kainic acid microinjection is sufficient to induce dystonia from the cerebellar vermis. The rats with tiagabine treatment were scored based on motor amelioration assessed via beam walking. Involuntary dystonic spasm was observed with repetitive rigidity, and twisting movements in the rats were also confirmed by a high score on the dystonic scoring and a high amplitude on the EMG data. Beam walking apparatus, telemetric electromyography (EMG) recording, and histological verification were performed to confirm dystonic symptoms in the rats on post-surgery treatment. injected into kainic acid induced, cerebellar dystonic adult rats, and the effects were compared with non-tiagabine injected and sham-operated groups. The study of GABAergic drugs as an alternative treatment for cerebellar induced dystonia has not been reported.

Tiagabine is a selective GABA transporter inhibitor, which blocks the reuptake and recycling of GABA. In more recent studies, the cerebellum has also been identified as the possible target of dystonia, in the search for alternative treatments. The exaggerated movements have been studied and have implicated basal ganglia as the point of origin. Wang, Tsui-chin Ngampramuan, Sukonthar Kotchabhakdi, Naiphinichĭystonia is a neurological disorder characterized by excessive involuntary muscle contractions that lead to twisting movements.

Tiagabine treatment in kainic acid induced cerebellar lesion of dystonia rat model

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